Topoisomerase 2a
WebMay 3, 2024 · Topoisomerase 2a (Topo2a)-dependent G 2 arrest engenders faithful segregation of sister chromatids, yet in certain tumor cell lines where this arrest is … WebJan 20, 2024 · Instead, BAZ2A-TAM domain in association with RNA mediates the interaction with topoisomerase 2A (TOP2A) and histone demethylase KDM1A, whose expression positively correlates with BAZ2A levels in both localized and aggressive PCa. Pharmacological inhibition of TOP2A and KDM1A activities upregulates the expression of …
Topoisomerase 2a
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WebTopoisomerase 2A (TOP2A) is a key member of this family that prominently stains along the axis of mitotic chromosomes. Assessing mitotic-specific functions of TOP2A has been … WebApr 7, 2015 · Topoisomerase 2A (TOP2A), the key enzyme required for generating transient double-stranded breaks in DNA topological structure, played a significant role in DNA replication and transcription and the …
WebJun 4, 2024 · In silico screening of the interactions with the target proteins tubulin, human topoisomerase II β and human ROCK1 via docking calculation permitted the selection of the new molecules 1a–c, 2a–c and 3 . Their drug-likeness was computationally predicted regarding the physico-chemical properties relevant for the development of a drug. WebMar 27, 2024 · Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. ... [16, 28], thus could probably explain the poor correlation between TOP 2A protein expression and gene amplification. Since TOP2A protein represents the ultimate expression of TOP2A as well as tumor cell ...
WebSep 1, 2024 · However, recent studies have suggested that the topoisomerase 2a isozyme is predominantly responsible for the carcinogenic side effects associated with etoposide … WebAll lanes : Anti-Topoisomerase II alpha antibody [EP1102Y] (ab52934) at 1/1000 dilution Lane 1 : HeLa (human cervix adenocarcinoma) whole cell lysate Lane 2 : Jurkat (human …
WebDNA gyrase is a type II topoisomerase that introduces or removes negative supercoils, forms or resolves catenanes, and knots or unknots DNA ( Gellert et al., 1976; Kreuzer and …
WebMar 21, 2024 · TOP2A (DNA Topoisomerase II Alpha) is a Protein Coding gene. Diseases associated with TOP2A include Malignant Peripheral Nerve Sheath Tumor and Neuroblastoma . Among its related pathways are Transport of the SLBP independent Mature mRNA and Cell Cycle, Mitotic . Gene Ontology (GO) annotations related to this gene … st andrew milford bulletinWebJun 5, 2024 · Topoisomerase activities that modulate supercoiling and knotting of intracellular DNA. (A) Both topo I and topo II can relax the (+)S and (−)S of DNA generated, respectively, in front of and behind the transcribing complex.The DNA-swiveling mechanism of topo I performs nearby the RNA polymerase, whereas the DNA cross-inversion … st andrew moore oklahomaWebFeb 27, 2024 · The type 2 DNA topoisomerases (Top2) are conserved enzymes and biomarkers for cell proliferation. The catalytic activities of the human isoform Top2a are essential for the regulation of DNA ... st andrew morewoodWebApr 7, 2015 · This study aims to investigate clinical significance of topoisomerase 2A (TOP2A) expression and TOP2A gene change in operable invasive breast cancer. This is a retrospective analysis, which ... personal support worker jobWebMar 19, 2024 · Top2cc was detected using the Human Topoisomerase ICE Assay Kit (Cat #TG1020-2a; Topogen). The method of DNA purification was modified by combining the … personal support worker jobs saint john nbWebMay 3, 2024 · Topoisomerase 2a (Topo2a)-dependent G 2 arrest engenders faithful segregation of sister chromatids, yet in certain tumor cell lines where this arrest is dysfunctional, a PKCε-dependent failsafe pathway can be triggered. Here we elaborate on recent advances in understanding the underlying mechanisms associated with this G 2 … personal summary template• Watt PM, Hickson ID (November 1994). "Structure and function of type II DNA topoisomerases". The Biochemical Journal. 303 (Pt 3): 681–695. doi:10.1042/bj3030681. PMC 1137600. PMID 7980433. • Bronner C, Hopfner R, Mousli M (2002). "Transcriptional regulation of the human topoisomerase IIalpha gene". Anticancer Research. 22 (2A): 605–612. PMID 12014628. personal support worker jobs oshawa