Ionis tmprss6-lrx
WebThe β-thalassemias are a group of inherited hemoglobin disorders that represent a substantial global health burden. 1,2 Defective production of β-globin chains of adult hemoglobin causes an... Web2 mrt. 2024 · Ionis Pharmaceuticals Inc. developed TMPRSS6-silencing molecules with the commercial name IONIS-TMPRSS6-LRX, which are currently being tested in phase 1 clinical trials (ClinicalTrials.gov ...
Ionis tmprss6-lrx
Did you know?
Web27 mrt. 2024 · Blood samples for IONIS-TMPRSS6-Lrx PK will also be collected at the Early Termination visit for all cohorts (if it occurs). Urine for IONIS-TMPRSS6-Lrx PK will be collected at the following intervals: Cohorts A, B, and C: time of dosing on Day 1 to 24 hours post-dose on Day 2; time of dosing on Day 57 to 24 hours post-dose on Day 58. WebSapablursen, formerly known as IONIS-TMPRSS6-LRx, is an investigational ligand-conjugated antisense (LICA) medicine designed to target the TMPRSS6 gene to …
Web17 mrt. 2024 · Ionis comprehensively investigated structure-activity relationships of triantennary GalNAc-conjugated ASOs. 96 Seventeen GalNAc clusters were assembled … Web18 mei 2024 · The plasma pharmacokinetics (time taken to reach maximal concentration or Tmax) of Ionis TMPRSS6-Lrx will be assessed following single and multiple dose SC administration Pharmacokinetics after single and multiple doses of IONIS TMPRSS6-Lrx (Plasma terminal elimination half-life (t1/2λz) Time Frame: Up to 148 Days
WebThe EU Clinical Trials Register currently displays 43178 clinical trials with a EudraCT protocol, of which 7141 are clinical trials conducted with subjects less than 18 years old. The register also displays information on 18700 older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006). Web2 dec. 2016 · TMPRSS6 is predominantly expressed in hepatocytes, for which we have developed a targeted delivery approach with triantennary N-acetyl galactosamine (GalNAc). With GalNAc-conjugated ASOs, a ~10-fold improvement in potency is observed for many liver targets (Prakash et al. Nucleic Acids Res. 2014; 42(13):8796-807).
Web20 nov. 2024 · IONIS-TMPRSS6-LRx will be administered by SC injection every 4 weeks; Clinical Trial Outcome Measures Primary Measures. Change in the frequency of …
WebFor the biopharma industry investment, business development and competitive intelligence professionals who require information to support financing, partnering and licensing … side effects from premarin creamWeb18 mei 2024 · The purpose is to assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS TMPRSS6-Lrx Administered Subcutaneously for up to 44 Healthy Volunteers Study Overview Status Completed Conditions Thalassemia Intervention / Treatment Drug: IONIS TMPRSS6-Lrx Other: Placebo Study Type Interventional … side effects from proliaWebCARLSBAD, Calif., Nov. 27, 2024 /PRNewswire/ -- Ionis Pharmaceuticals, Inc. (NASDAQ: IONS), the leader in antisense therapeutics, today announced that data from the IONIS … the pink roadhouse oodnadattaWeb18 mei 2024 · Experimental: IONIS TMPRSS6-Lrx - Ascending single and multiple doses of IONIS TMPRSS6-Lrx administered subcutaneously Placebo Comparator: Placebo - Saline .9% Treatment: Drugs: IONIS TMPRSS6-Lrx Ascending single and multiple doses of IONIS TMPRSS6-Lrx administered subcutaneously side effects from prilosec otcWebIONIS-TMPRSS6-LRx Trial Design 4 Treatment Groups OG-6219 Dose 2 1 of 4 OG-6219 Dose 1 1 of 4 OG-6219 Dose 3 1 of 4 Placebo 1 of 4 Experimental Treatment Non-Treatment Group 380 Total Participants · 4 Treatment Groups Primary Treatment: OG-6219 Dose 2 · Has Placebo Group · Phase 2 OG-6219 Dose 2 Drug side effects from pre workoutWeb22 jan. 2024 · The plasma pharmacokinetics (maximum observed drug concentration or Cmax) of Ionis TMPRSS6-Lrx will be assessed following single and multiple dose SC … side effects from pneumoniaWebIONIS-MAPT Rx is being developed to treat people with Alzheimer’s disease (AD) and potentially other neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain, such as certain forms of … side effects from prednisone in dogs