Consomic strain

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August undefined, 2024

WebStrain State: Strain Type: Any closed colony coisogenic strain congenic strain consomic or chromosome substitution strain hybrid inbred strain major histocompatibility congenic minor histocompatibility congenic mutant stock mutant strain noninbred stock outbred stock recombinant congenic recombinant inbred segregating inbred unclassified wild ... WebNov 24, 2008 · Consomic strains have recently attracted attention as an advantageous method to screen for genes related to developmental, physiological, and behavioral phenotypes. Recently, a new set of consomic strains was established from the Japanese wild-derived mouse strain MSM/Ms and C57BL/6JJcl. By analyzing the entire consomic …

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WebGenetic background affects susceptibility to pancreatic ductal adenocarcinoma in the Ela-KRASG12D mouse model. In this model, KRAS oncogene expression is driven by an elastase promoter in acinar cells of the pancreas on an FVB/NTac (FVB) background WebThe SMSR is a resource of special strains of mice that are important tools for genetic analysis of such complex diseases. They include panels of recombinant inbred (RI) and … jeffrey simpson globe and mail

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WebA congenic strain is derived by mating mice carrying a foreign gene of interest in each succeeding generation to mice of an inbred strain. A fully congenic strain and the inbred … WebIt is relatively easy to generate inbred congenic (nearly identical) and consomic strains. A consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain via a series of marker-assisted backcrosses. Rat, rattus norvegicus, model, systems, organisms, homology. WebJun 29, 2016 · Background: Selecting chromosome substitution strains (CSSs, also called consomic strains/lines) used in the search for quantitative trait loci (QTLs) consistently … jeffrey simmons tennessee titans twitter

(PDF) Commentary: Mouse Genetic Nomenclature: Standardization of Strain ...

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http://www.informatics.jax.org/mgihome/nomen/strains.shtml WebNov 1, 2015 · This creates the consomic strain that shares with its host strain the same 1) genetic background (including chrY PAR, autosomes, chrX, mitochondrial DNA) and 2) pre- and postnatal maternal environment (including inoculated microbiota). oyo flagship 703240 pride innWebApr 1, 2008 · Genomes of consomic mouse strains. Centromeres are shown at the top. (Green) MSM/Ms-derived chromosomes; (blue) B6 chromosomes. The genetic background and mitochondria DNA were confirmed to be ... oyo flagship 71229 krishna residency

"WebCongenic (and consomic) strains contain a discrete DNA region derived from another strain (for consomic strains, this region is an entire chromosome; Table 31.1). Historically, congenic mice were developed by the repeated backcrossing of strain-specific alleles onto another strain background with the selection of the desired allele/region at ... " - Consomic strain

Consomic strain

WebA consomic strain of animals is an inbred strain in which a whole chromosome – rather than one local chromosomal region – is replaced from a donor strain onto a recipient background. This is performed by marker-assisted breeding; the donor strain is backcrossed to the recipient strain for over eight generations and progeny (generally … WebMar 3, 2010 · Chromosome 13 consomic and congenic rat strains were analyzed to investigate the pattern of genomic pathway utilization involved in protection against salt …

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WebJul 23, 2024 · The congenic strain R3 (C3H.NSY- [ D11Mit242-D11Mit168 ]) possessed the middle and distal region (segment C, D and E) of NSY-Chr 11 from the recombinant position between D11Mit274 and D11Mit242 to the telomere of Chr 11. WebAn inbred strain that contains a single entire chromosome from another strain. Consomic (or Chromosome Substitution Strains) are derived by backcrossing to a parental inbred …

Backcrossing may be deliberately employed in animals to transfer a desirable trait in an animal of inferior genetic background to an animal of preferable genetic background. In gene-knockout experiments in particular, where the knockout is performed on easily cultured stem cell lines, but is required in an animal with a different genetic background, the knockout animal is backcrossed against the animal of the required genetic background. As the figure shows, each time that the … WebMar 1, 2003 · Like the consomic strains, these congenic strains also represent a renewable resource. The use of congenic strains has been very limited until this time because development of a congenic line typically requires 10–12 generations of backcrossing, after completion of the crossbreeding studies to define the QTL of interest. ...

WebStrains Made from Multiple Inbred Strains 4.1 Recombinant Inbred Strains 4.2 Mixed Inbred Strains 4.3 Recombinant Congenic Strains 4.4 Advanced Intercross Lines 5. … Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆

WebA consomic rat strain is one in which an entire chromosome is introgressed into the isogenic background of another inbred strain using marker-assisted selection. The …

WebB. Consomic Strains The process of generating congenic strains is very lengthy, because it takes many backcrosses to obtain an isogenic or homogeneous background. … oyo flagship 70333 shree saiji palaceWebany consomic strain within 6 months, by an F2 intercross of the consomic with the background parental strain. These rats are likely to become a national resource for rat research. The website, which currently gets 2,000 visits per month (figure 3), enables investigators to download data or to use the analytical jeffrey simons ohioWebMar 3, 2010 · Chromosome 13 consomic and congenic rat strains were analyzed to investigate the pattern of genomic pathway utilization involved in protection against salt-sensitive hypertension and renal injury. Introgression of the entire Brown-Norway chromosome 13 (consomic SS-13(BN)) or nonoverlapping segments … jeffrey simpkins williamson wvWebApr 4, 2024 · 5.3.1 Consomic Strains 5.4 Segregating Inbred Strains 5.5 Conplastic Strains 6. Outbreds and Closed Colonies 6.1 Outbreds 6.2 Closed Colonies 7. ES cell … oyo flagship 703826 hotel arjun palace innWebFeb 11, 2015 · Using experimental allergic encephalomyelitis (EAE), a mouse model of MS, we evaluated genetic control of disease course among a panel of 26 consomic strains of mice inheriting chromosomes from the wild-derived PWD strain on the C57BL/6J background, which models the genetic diversity seen in human populations. jeffrey singer cato instituteWebConsomic strains are special type of congenic strains. The differential segment between the consomic strain and its parental (progenitor) strain is represented by a whole chromosome. Consomic strains are often used … jeffrey singleton us steelWebA chromosome substitution strain (CSS) or consomic strain is an inbred strain in which a single chromosome from a donor strain replaces the corresponding chromosome in … jeffrey sims coach